Researchers from the University of Texas at Austin have developed a laser-based ray device that can change the size and shape of a block of gel-like material that has human or bacterial cells growing on it, an innovation that could help scientists understand how to someday grow replacement tissues and organs for implants. The ‘shrink ray’ is a near-infrared laser that can be focused on small points inside the substrate—the material used to grow cells. On the microscopic level, the substrate is made of proteins jumbled and intertwined. When the laser strikes a point within the substrate, new chemical bonds are formed between the proteins. This draws the proteins in more tightly, which alters the surface shape as it’s tugged on from below.
The device can selectively change the shape and texture of the surface by controlling precisely which parts of the interior of the material shrink, enabling the researchers to create specific 3D features on the surface including bumps, grooves, and rings. The researchers also can change the location and shapes of surface features over time by mimicking the dynamic nature of the environment in which cells typically live, grow and move.
While other methods heat or chemically alter the surface to change the substrate under living cells, damaging living cells or causing them to unstick from the surface, the new device allows the formation of any 3D pattern on demand while viewing the growing cells through a microscope.
The researchers plan to use the tool to investigate fundamental scientific questions surrounding cellular growth and migration, which could lead to more materials and procedures that would promote wound healing and nerve regrowth or assist in growing and successfully implanting replacement tissues like skin or heart valves.
The study was published in the Journal of the American Chemical Society.