|Professor Adrian Mulholland et al., from the University of Bristol used computer simulations to reveal how bacteria are able to destroy antibiotics – a breakthrough which will help develop drugs that can effectively tackle infections in the future. They focused on the role of enzymes in the bacteria, which split the structure of the antibiotic and stops it from working, making the bacteria resistant. The findings published in the journal Chemical Communications, will help scientists to choose the best medicines for specific outbreaks and develop new antibiotics with a much lower risk of resistance.
The researchers used a special Nobel Prize-winning technique called QM/MM – quantum mechanics/molecular mechanics simulations- to learn how enzymes called ‘beta-lactamases’ react to antibiotics. The computer simulations revealed that the most important stage in the process is
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