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Madame Marie Sklodowska Curie (1867–1934)- The First Lady in Nobel Prize History

Imagine having to make do with primitive lab facilities to undertake pioneering research. Imagine not being fully acknowledged for revolutionary scientific work because of the belief that women scientists could only play a supporting role when it came to significant research. Imagine being plagued by ill health and unbearable fatigue, directly resulting from the kind of research work engaged in, but carrying on regardless, with an almost maniacal devotion, not to mention severe bouts of depression and the strain of dealing with scandalous gossip and xenophobia.

Madame Curie took all this and more in her stride and in addition, produced trendsetting scientific work that took the world by storm.

An outstanding scientist of many firsts, Marie Curie was the first woman to win a Nobel Prize, the first person to win it twice (1903 in Physics, and 1911 in Chemistry), the first woman to get a Ph.D. in France, the first woman to teach at the Sorbonne, and in later years, the first Nobel Laureate whose child too went on to win a Nobel Prize, her first-born, Irene, having won it in Chemistry in 1935. Not just that, till today, she remains the only person, man or woman, to be honoured with the Nobel Prize in two different sciences. In a way, Marie Curie’s life shines a light on how excelling in scientific work was doubly difficult for women during her time, and how her determination to achieve her goals despite formidable barriers, has paved the way for other women scientists to follow in her footsteps.

Early Life in Poland

Born Maria Sklodowska in 1867 in Warsaw, in Russian-occupied Poland, Mme. Curie grew up under the shadow of tyrannies inflicted by the Russian regime. With university education being out of bounds for Polish girls under the Russian rule, in the beginning, Maria’s father, a teacher of physics and chemistry, sent her and her elder sister Bronya to a floating night university that held classes for young women clandestinely in different private residences.

However, the two sisters had set their hearts on pursuing higher studies in Paris, something their father could ill afford. Maria worked as a governess for three years to help her father pay for Bronya’s medical studies in Paris, so Bronya, after starting her practice, could then help pay for her own educational costs there.

An outstanding scientist of many firsts, Marie Curie was the first woman to win a Nobel Prize, the first person to win it twice (1903 in Physics, and 1911 in Chemistry), the first woman to get a Ph.D. in France, the first woman to teach at the Sorbonne, and in later years, the first Nobel Laureate whose child too went on to win a Nobel Prize, her first-born, Irene, having won it in Chemistry in 1935. Not just that, till today, she remains the only person, man or woman, to be honoured with the Nobel Prize in two different sciences.

University education in Paris

When Maria finally went to Paris in 1891, she was 24. She took on the French name Marie, enrolled at the Sorbonne, and notwithstanding limited resources, got her Master’s degree in physics in two years, and a year later, a second degree in mathematics. Some French scientists, impressed by Marie’s aptitude for learning and research, helped her complete the second degree by getting her a scholarship meant for an outstanding Polish student.

While studying for her Master’s in mathematics, Marie got a job from the Society for the Encouragement of National Industry for carrying out research relating magnetic properties of different steels to their chemical composition. But, she needed a lab to do the commissioned work. A Polish professor she knew introduced her to his colleague, Pierre Curie, who though holding a low-profile position as the laboratory supervisor at a municipal industrial school, was already well-known for his pioneering research on magnetism and the precise instruments he had invented for his work.

Pierre was then 34 and still living with his parents. With Marie sharing space with him in his lab, the relationship between the two of them transitioned from intellectual affinity and mutual respect to love. This development in the lives of Marie Sklodowska and Pierre Curie would dramatically change their personal lives and the course of science.

A dynamic couple obsessed with research work

Pierre, who had done enough seminal research over the past 15 years to earn him a doctorate, was stagnating at the bottom of the academic ladder. Marie motivated him to complete writing his research paper on magnetism and in March 1895, he was awarded the doctorate degree and also offered a professorship at the municipal trade school with a slightly higher salary.

In July that year, Marie and Pierre were married in a simple civil ceremony. When a family member offered to buy her a wedding dress, Marie requested that it be “practical and dark” so she could “put it on afterward to go to the laboratory”. The couple used the money they were gifted at their wedding to buy bicycles for themselves and spent the summer cycling through the countryside. In the years that followed, they continued to go on long cycle rides whenever they wanted to relax.

Ground-breaking discoveries

On completing her research on the magnetic properties of steel, though Pierre and she were barely managing to make ends meet, Marie used part of the payment she received to return the scholarship money she had received as a university student, although she was not required to. She repaid it to help some other deserving Polish student pursue advanced studies.

Choosing to work on the largely ignored Becquerel rays for her thesis, Mme. Curie, like other scientists, was baffled about the source of the high-energy radiations emitted by uranium compounds. She put forward a daring hypothesis postulating that these emissions could be a property built into the very structure of the atoms of uranium. Till then, the atom was thought to be indivisible and nobody had as yet understood the inner structure of an atom or the immense energy it contained. Mme. Curie was also sure a small sample of pitchblende she was testing could contain some undiscovered elements.

By now, hugely interested in what Marie was researching, Pierre gave up his work on crystals and joined her to expedite the new discoveries – two new elements they named ‘polonium’ (after Marie’s native country) and ‘radium’ (derived from a term Marie was to coin). The Curies published papers on the two new elements they had discovered. Marie invented the word ‘radioactive’ to describe them, and the rest, as they say, is history.

Pierre was then 34, and still living with his parents. With Marie sharing space with him in his lab, the relationship between the two of them transitioned from intellectual affinity and mutual respect to love. This development in the lives of Marie Sklodowska and Pierre Curie would dramatically change their personal lives and the course of science.

Nobel Prizes: Appreciation and Agony

Marie, with the help of Pierre, spent almost three years, arduously processing over a ton of pitchblende to isolate one decigram of radium chloride and finally presented her doctoral thesis on ‘Research on Radioactive Substances’ in June 1903. Those reviewing her thesis commented that Mme. Curie’s findings represented the greatest scientific contribution ever made in a doctoral thesis. True to character, Marie bought a black dress to wear to a small private celebration to felicitate her achievement of being the first woman to be awarded a doctorate in France, so that just like the navy-blue dress she had worn at her wedding, she could wear this one too in the lab without any stains showing.

Later that year, Marie and Pierre along with Henri Becquerel, were awarded the Nobel Prize in Physics for their revolutionary work on radioactivity. But, Marie almost didn’t get the honour. A few scientists believed only Becquerel and Pierre could have done all the hard work and had objected to Marie’s inclusion. The award citation itself avoided any specific mention of the Curies’ discovery of polonium and radium as some chemists on the nominating committee insisted that the Curies could deserve a Nobel Prize for Chemistry in the future once they isolated the new elements in more substantial amounts.

The Nobel Prize brought the Curies international recognition and improved their life somewhat. However, upholding the humanitarian ideals of science, they refused to patent their discovery of radium and cash in on the demand for it, making all their research work publicly available. Experts who visited their ‘lab’ were stunned that Mme. Curie could have accurately determined the atomic weight of radium in such dinghy conditions. In recognition of their award-winning work, the French government finally offered Pierre professorship at the Sorbonne in 1904 and promised him a new lab.

Working with radioactive substances had already begun taking its toll on Marie’s and Pierre’s health. The skin on their hands was cracked and scarred and they experienced weakness in their limbs due to the radioactive emissions corroding their bones. Today, the notebooks in which they recorded their work are kept under lock and key because of how highly radioactive they are. Those who need access to them have to do so at their own risk. In fact, due to ill health and their on-going work, the Curies could travel to Stockholm only in June 1905, thus receiving their award two years after it was announced. When Pierre delivered the acceptance lecture, he made it a point to distinguish between Marie’s independent research work and the work on which they had collaborated.

The very next year, Pierre died tragically on being run over by a fully-laden, horse-drawn wagon, and then Marie went through another bout of depression. Instead of a widow’s pension, in 1908, she accepted the offer to teach at the Sorbonne in Pierre’s place, becoming the first woman to teach there.

In 1911, just when she was selected for a second Nobel Prize, this time in Chemistry for the discovery of radium and polonium, the French press was awash with slanderous articles about her alleged affair with one of her late husband’s most brilliant students, Paul Langevin, a married man already living apart from his wife. Marie was painted as the foreign home wrecker who had destroyed a French woman’s marriage. Pressurised by some not to go to Sweden to accept the Nobel Prize because of the scandalous stories in the press, Marie went there, all the same, deciding to stand up for the integrity of her work. “I believe there is no connection between my scientific work and the facts of private life,” was her reply to one critic. In her acceptance speech, she paid a tribute to Pierre, besides also describing her independent work.

Later life

Marie was getting ready to set up the Radium Institute in Paris when World War I broke out. Appalled by the way military hospitals were operating without X-Ray equipment, sometimes chopping off limbs that could have been saved, she set up around 20 mobile X-ray stations for treating wounded soldiers on the frontlines, sometimes driving one of the cars and even operating the machines herself. In addition, she helped set up around 200 permanent X-ray centres during the war.

Established with help from philanthropists, the French government, and friends and well-wishers from the US and other parts of the world, the Radium Institute is a world centre for radium research.

Madame Curie died on 4 July 1934 of a blood disorder that had gone undetected for some time. Though she and Pierre were first buried in the Curie family plot near Paris, their remains were re-interred in 1995 in the Pantheon, France’s national mausoleum for eminent French citizens. On that occasion, the then French President, Francois Mitterrand paid a tribute to Pierre and Marie and a special one to Marie saying, “As the country bows before her ashes… I form the wish, in the name of France, that everywhere in the world the equality of the rights of women and men might progress.”

References

  1. Nobelprize.org. Nobel Media AB 2014: Marie Curie – Facts – https://www.nobelprize.org/nobel_prizes/chemistry/laureates/1911/marie-curie-facts.html
  2. Nobelprize.org. Nobel Media AB 2014: Marie and Pierre Curie and the Discovery of Polonium and Radium – https://www.nobelprize.org/nobel_prizes/themes/physics/curie/
  3. American Institute of Physics, Naomi Pasachoff: Marie Curie and the Science of Radioactivity – https://history.aip.org/exhibits/curie/polgirl1.htm
  4. Julie Des Jardins: Madame Curie’s passion – Smithsonian magazine, October 2011
  5. Sara Rockwell: The life and legacy of Marie Curie – Yale Journal of Biology and Medicine, 76(4-6), 2003
  6. The Biography.com website: Marie Curie Biography.com – https://www.biography.com/people/marie-curie-9263538
  7. Robert Krulwich: Don’t Come to Stockholm! Madame Curie’s Nobel Scandal – National Public Radio, 14 December 2010

Chemical Industry Digest- Jan 2018

Articles covered in this issue:

Key direct tax expectations of India chemicals sector from Budget 2018
Aashish Kasad, EY India.
A brief writeup on the author’s views on the needed tax proposals for the chemical industry.

Operational Excellence: Emerges From Multiple Dimensions 
O P Goyal, Institute of Chemical Technology, Mumbai
How to get the best out of existing assets through operational excellence in every area of manufacturing and business can make the difference between great success and the average.

Proposed Methanol Economy Fund – Ground Realities need to be considere
N S Venkataraman, Founder and Director, Nandini Consultancy Centre
This article provides a brief on the methanol scenario in India from capacities to production, technology and feedstock issues and the options for India.

Indian Hydrocarbon Scenario
Chemical Industry Digest Research Group
Oil & gas and Refinery sectors are very crucial to the Indian economy as they provide the life sustaining energy to fuel industries and provide feedstocks for the chemical industry. Article reviews these sectors in the context of emerging disruptive developments and current needs of the country.

Will Indian Fertilizer Industry see changes soon?
Piyush Nimgaonkar, Senior Manager, Care Ratings Ltd.
Reviews the urea fertiliser sector in India, the current government policies, revival strategies etc.

The Challenges in the Specialty Chemicals Industry
Dr. N C Dutta, Consultant, Modicon Pvt Ltd
The author underlines the constraints and challenges facing the specialty chemicals industry, which if addressed, can lead to astronomical growth of the industry as India has all the required ingredients to achieve this.

Pigment Industry: Hype or Hope. An overview of Pigments industry
Sambit Roy, Head BU Pigments – India Region, Clariant
This article reviews the overall pigments industry globally and in India. It also provides a glimpse into the emerging areas of high performance and special effect pigments.

Digital technologies in healthcare and pharmaceuticals industry: Emerging perspectives
MedTech Asia Research Group, Mumbai
This article gives a comprehensive overview of advanced digital technologies and its enabling impact and applications and how it will be transforming the health sector with many examples.

Challenges facing the Indian Chlor-Alkali Industry
Chemical Industry Digest Research Group
Though these are commodity inorganic chemicals, the chlor-alkali industry, whose products include basic chemicals such as caustic soda, chlorine, soda ash is very important for the working of many chemical industries. The challenges it faces and possible solutions are discussed.

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Inspection lamps for non-destructive testing and aerospace applications introduced

Spectronics Corporation has released the uVision™ UV-365HC and mobile UV-365MHC, a new group of high-intensity ASTM E3022-15 Compliant LED UV-A lamps for non-destructive testing, aerospace, and other fluorescent inspection applications. The high-intensity feature provides superior fluorescent response while remaining within ASTM E3022-15 compliance. Fluorescent indications are perceptible and easily spotted.
The uVision™ Series hallmark with IP65 rating signifies the unit can be fully covered in dust without any foreign material entering the housing. It also means that the unit is protected against jets of water from all directions. All uVision™ Series lamps are constructed with a fan-less, cool running design that enable the lamps to operate at temperatures reaching upwards of 122° F. Whether it is heat, dust, or moisture, the rugged outer housing and sealed design can withstand the toughest exposure.
The uVision™ Series lamps consist of three powerful UV-A LEDs for fluorescent inspection and one white light LED for visual inspection. These high-quality LEDs provide a uniform beam profile and wide coverage area. The uVision™ UV-A lenses are long-lasting and able to endure rigorous use, offsetting the effects of lens deterioration. Also, these lamps are compact, lightweight, and ergonomic.
The mobile battery operated UV-365MHC is easy to use and allows for in-the-field inspections. The battery indicator light on the back panel of the lamp ensures the battery is never depleted while in use.

Chemical Industry Digest- December 2017

Articles covered in this issue:

Understanding the basics of ‘Tolerable Risk’
Shivendra Kapoor – Chola MS Risk Services.
It is important, the author emphasises, to know and quantify in precise terms what is the tolerable risk for a process plant. Without knowing the level of tolerable risk no consultant or internal industry operator can bring a facility to the standards required for proactive safety practices.

Is your Process Safe ? SIL, SIS, SFF PHA etc. Demystified !
S Raghava Chari – Industry Consultant
This article describes various techniques employed in process industries to ensure the safe operation of process plants. The author explains with examples on understanding risk, process hazard analysis, probability of failures, safety instrumented systems and functioning and other terms against the background of process operations.

Failure Analysis of boiler bank tubes of HRSG and comparative study for integrity assessment . . .
Maushumi Kakoti Talukdar, Abhay Kujur, Anil Bhardwaj – IEOT, Phase II, ONGC.
Safety is of paramount importance and cannot be compromised. Boilers are critical equipment which have to be proactively maintained so that no unsafe incidents take place. This case study based on failure analysis of heat recovery steam generators provides conclusions on corrosion based deterioration of tube material.

Transforming refinery operations via software innovations
Ron Beck, Sunil Patil – AspenTech . . . 
The digital world driven by softwares and computers and now leapfrogging into artificial intelligence and Internet of Things can do wonders to industry. This article projects the potential of latest softwares, particularly in complex operations like in refineries, to derive greater efficiencies in every area of a plant’s operation. How software advances capabilities in three areas: Energy optimisation, reliability and Process Safety are described in detail.

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Sir Ernest Rutherford (1871–1937)

Sir Ernest Rutherford (1871–1937)
The Founder of Nuclear Science

A passionate, indefatigable researcher, Sir Ernest Rutherford is acknowledged to have initiated the era of big science around the dawn of the 20th century. His remarkable discoveries of the concept of radioactive half-life, of the alpha and beta particles, the atomic nucleus, and the proton inspired many more scientists such as Niels Bohr to carry out further research in atomic science. But it was his ground-breaking discovery, that an atom is mostly empty space and that almost all of its mass was concentrated in a tiny nucleus at the centre, that set the stage for the commencement of nuclear physics and nuclear chemistry.

Rutherford’s extensive body of research won him so many awards, it is believed that his collection of medals is the largest ever awarded to any one scientist. Quite rightly, one of his recent biographers, John Campbell, paid him the ultimate tribute referring to him as the ‘Scientist Supreme’, even going on to add: He (Rutherford) is to the atom what Darwin is to evolution, Newton to mechanics, Faraday to electricity, and Einstein to relativity.

The celebrated scientist Sir J. J. Thomson, discoverer of the first subatomic particle – the electron, and winner of the Nobel Prize in Physics in 1906, mentored Rutherford as a postgraduate student from 1895 to 1898. Greatly impressed by his new student, not by his height, athletic built, and vivid blue eyes, but his potential for scientific work, he said, “I have never had a student with more enthusiasm or ability for original research than Mr. Rutherford.”

The Nobel Prize in Chemistry that Rutherford was awarded in 1908 for “his investigations into the disintegration of the elements, and the chemistry of radioactive substances” was a recognition of the significance of his scientific work and his stature as an exceptional researcher. Not just that, Rutherford’s boundless enthusiasm for original research was so inspiring that an astonishingly large number of scientists who carried out research under his guidance or alongside him, namely, James Chadwick, Cecil Powell, Niels Bohr, Otto Hahn, Frederick Soddy, John Cockcroft, Ernest Walton and Edward Appleton went on to become Nobel Prize winners too.

Early Life

Ernest Rutherford was born on 30 August 1971 in rural Spring Grove (now called Brightwater), not far from the town of Nelson in New Zealand’s South Island. The fourth child of James Rutherford, a farmer, and Martha Thompson, a teacher, he was one of 12 children. His mother believed ‘all knowledge is power’, and so, despite money being tight, she and Rutherford’s dad made sure all their children were well educated.

Rutherford had a hard life as a boy and is known to have famously said that his inclination towards innovative research sprang from having had to find inventive ways of living with limited resources in a poor family. He said as a child he used to tell himself, “We haven’t got the money, so we’ve got to think.”

Having earned a scholarship in 1890 to study at the University of New Zealand’s Canterbury College in Christchurch, Rutherford graduated with three degrees in four years. A B.A. in pure mathematics and Latin (both compulsory subjects), applied mathematics, English, French, and physics in 1892; an M.A. with double first-class honours in mathematics and mathematical physics, and also in physical science (electricity and magnetism) in 1893; and just one year later, on the strength of the independent research he carried out on the ability of high-frequency electrical discharge to magnetize iron, he got his Bachelor of Science degree in chemistry and geology.

In 1895, Rutherford won another scholarship to pursue postgraduate studies in the UK. At 24, armed with his three degrees, he joined the University of Cambridge where he began studying and researching at the Cavendish Laboratory headed by J. J. Thomson. He was the first non-Cambridge research student to study there.

Revolutionary scientific contributions

Thomson was tremendously taken up by the kind of advanced research Rutherford was capable of at a young age. So, in 1902, when Montreal’s McGill University was looking for a new Chair of Physics, he recommended Rutherford for that position. Rutherford was just 27 when he sailed to Canada to accept the professorship at McGill. It was here that he carried out the research that won him the Nobel Prize – research on the radiations emitted when radioactive elements decayed. But by the time he got the award in 1908, he had already moved back to the UK where he was appointed as the Chair of Physics of the University of Manchester.

Rutherford made his most important discovery after being awarded the Nobel Prize. The University of Manchester was where, under his guidance, his researchers Hans Geiger and Ernest Marsden carried out the famous gold foil experiment. The astonishing results of this experiment led to Rutherford’s discovery of the atomic nucleus in 1910, and to his nuclear model of the atom replacing J. J. Thomson’s earlier plum pudding model.

In 1912, fascinated by Rutherford’s discovery, Niels Bohr, then a young 26-year old researcher joined his laboratory in Manchester as a research student. Bohr adapted Rutherford’s atomic model to Max Plank’s quantum theory, resulting in the first quantum model of the atom – the Rutherford-Bohr atom. After that, Rutherford and Bohr became close friends and in later years often spent vacations together along with their wives.

Continuing with his experiments in atomic science, a few years later, in 1917, when Rutherford bombarded nitrogen atoms with alpha particles and converted them into oxygen atoms, he not only became the first scientist to split the atom, he also turned out to be the world’s first successful alchemist. The results of this research were published in 1919. That same year, things came full circle for him when he moved back to the Cavendish Laboratory at Cambridge where he had first started his research work in the UK with J. J. Thomson as his mentor. Only, this time he was there to be made the Director of the Laboratory and its Professor of Physics following the retirement of Sir J. J. Thomson.

Awards and honours

Rutherford was awarded numerous prestigious medals, prizes, honorary degrees and doctorates from different countries, in addition to fellowships of reputed societies and organisations. He was also the President of the Royal Society. He continued to be honoured even after his sudden death in 1937. Several countries including New Zealand, the UK, Sweden, and Canada issued postage stamps in his honour, and buildings and institutions in different parts of the world were named after him. In 1969, element 104 was named rutherfordium as a tribute to him. In 1991, the Rutherford Origin, an attractively set up outdoor display of Rutherford’s life and scientific work built on the site of his birth was opened in the presence of his grandchildren. In 1992, New Zealand issued a new $100 banknote featuring his portrait.

Rutherford was knighted in 1914, and given the title of Sir Ernest Rutherford. In 1925, he was appointed to the Order of Merit. When he visited New Zealand that year to deliver public lectures and visit his aged parents, he was felicitated as an illustrious New Zealander. People packed the halls where he delivered lectures on the structure of the atom.

But this also turned out to be his last visit to his home country. He died unexpectedly in Cambridge on October 19, 1937 at the age of 66 following surgical complications. A small delay in being operated upon for a partially strangulated umbilical hernia could possibly have led to his untimely death.

Rutherford’s ashes were interred in the nave of Westminster Abbey close to the tombs of Sir Isaac Newton and Lord Kelvin. Three years later, the remains of his mentor, Sir J. J. Thomson were buried next to him.

References

  1. NobelPrize.org: Ernest Rutherford – Biographical – Nobel Media AB 2014, http://www.nobelprize.org/nobel_prizes/chemistry/laureates/1908/rutherford-bio.html
  2. Famous Scientists: Ernest Rutherford – www.famousscientists.org/ernest-rutherford
  3. John Campbell: Rutherford – A Brief Biography – The World and I magazine, June 2011
  4. John Campbell: Rutherford, Ernest – Encyclopaedia of New Zealand, https://teara.govt.nz/en/biographies/3r37/rutherford-ernest
  5. New Zealand History: Ernest Rutherford Biography – https://nzhistory.govt.nz/people/ernest-rutherford
  6. Biography.com: Ernest Rutherford – Physicist, Scientist (1871 – 1937) – https://www.biography.com/people/ernest-rutherford-39099

Oxygen – The life-sustaining element

The first element of Group 16 of the periodic table, oxygen is the element on which our very existence on earth depends. Humans and almost all life forms on earth need it for every breath they take and for producing energy through the combustion of food within their body. Moreover, it’s the presence of oxygen in our atmosphere that sets our planet apart from all the others in our solar system.

Oxygen is the most abundant element on the earth, accounting for around 21% of the volume of its atmosphere, around 50% of the mass of its crust, and nine tenths of the mass of water. Besides, oxygen dissolved in oceans and other water bodies enables fish and marine life to breathe. It also constitutes two thirds of the mass of the human body.

A chemically reactive, non-metallic element, oxygen forms compounds with almost all chemical elements except the noble gases. It is so highly reactive, it’s amazing that we have free oxygen available in the atmosphere for breathing. But, what’s even more amazing is that most of us take this availability for granted and fail to realise or remember how this is made possible.

The fact is, the process of photosynthesis is responsible for almost all the free, breathable oxygen gas in our atmosphere. Half of the available oxygen is produced by photosynthetic organisms in water, the other half by plants and trees on land. All of these life forms use sunlight to convert inorganic compounds like carbon dioxide and water into carbohydrate molecules inside which they store chemical energy, and oxygen molecules which they release into the air. Thus, the oxygen we breathe is mainly a by-product of photosynthesis. Meaning, as long as we ensure we have enough trees and plants, we can ensure the replenishment of atmospheric oxygen.

How oxygen was discovered

The composition of air was somewhat of a mystery till around 250 years ago. Before that, for more than two millennia, it was believed that air was one of the five basic elements, the other four being earth, water, fire, and ether. It may seem somewhat naïve now, but air was formerly considered to be a single element. The process of burning, and the reactions involved, were also not clearly understood then, mainly because of the lack of proper laboratory equipment in those days for collecting air samples and examining them.

The Italian painter-scientist Leonardo da Vinci (1452-1519) is believed to be the first to suggest that air consists of at least two different gases, one of which was consumed during burning.

Then, in 1771, the radical, free-thinking, British theologian-scientist Joseph Priestley, intrigued by how a burning candle placed in an airtight jar was extinguished after sometime and how a mouse died within a few minutes of being placed inside one, began conducting a series of experiments to understand why this happened. Discovering that a half-dead mouse inside a sealed jar could be revived by introducing a sprig of mint inside the jar, and exposing the jar to sunlight, he concluded that plants seemed to release some refreshing gas. He even wrote to his friend, the American scientist Benjamin Franklin, saying he wished what he discovered would stop people from felling too many trees. Priestly also noticed that placing a green plant inside a closed jar for some days and then burning a candle inside it let the candle burn longer. With these experiments, Priestley became the first scientist to discover that plants release into the air a gas that animals need for breathing. We now call this process photosynthesis. But, Priestley was yet to identify his mystery gas as oxygen.

He only isolated it on 1 August, 1774 when he heated mercuric oxide and found that the gas it emitted could reignite a glowing ember, make a flame burn more intensely, and keep a mouse alive four times longer than a similar quantity of air. When he reported his findings, he said the mouse “was taken out quite vigorous”. He tried breathing the gas himself and discovered it did make him feel refreshed. By now he had decided to call his discovery “dephlogisticated air”. In those days, scientists believed that combustible substances released something called phlogiston when they were burned, and that the burning stopped when the surrounding air was saturated with phlogiston.

Three years earlier, in 1771, the Swedish apothecary Carl Wilhelm Scheele had independently isolated the same gas as Priestley and named it “fire air”, noticing that it produced sparks on coming into contact with charcoal dust. But, he published his findings only in 1777. By then, Priestley had already carried out several experiments on his discovery and published the results, also declaring that “air is not an elementary substance, but a composition,” of a mix of gases.

When Priestley discussed the properties of the new gas with the French chemist Lavoisier in 1775, the latter realised he had found just what he was looking for to disprove the phlogiston theory. He realised that combustion does not result in the release of ‘phlogiston’ but in a chemical reaction between the combustible substance and Priestley’s gas. He repeated Priestley’s experiments and recognised the gas as a new element. The name Lavoisier gave it – oxygen, was derived from the Greek words ‘oxy genes’ meaning ‘acid forming’ as he believed this element was an essential component for all acids.

The name Lavoisier gave it – oxygen, was derived from the Greek words ‘oxy genes’ meaning ‘acid forming’ as he believed this element was an essential component for all acids.

Importance and uses of oxygen

Vital for good health: Of the hundreds of tasks oxygen performs in our body, the three main ones include energy production, purification of blood, and detoxification. Deficiency of oxygen can result in fatigue and body weakness, and also in a slowing down of the detoxification processes that in turn could lead to various sicknesses including metabolic disorders and cancer. Maintaining the right proportion of oxygen in the atmosphere is even more important today considering the higher levels of air pollution, modern lifestyles characterised by lack of exercise, and an increase in the consumption of refined foods.

Use in healthcare: Oxygen compressed in cylinders is supplied to patients in emergency rooms and in the ICU, and used for treating people having respiratory problems such as asthma and COPD. It is also essential for mountain climbers, underwater divers, and astronauts. Besides, oxygen gas is used to destroy gangrene-causing bacteria and for treating carbon monoxide poisoning.

Provides protection from harmful sunrays: Oxygen forms a protective ozone layer in the stratosphere that absorbs hazardous UV rays from the sun and prevents them from harming life forms and ecosystems on the earth.

Industrial uses: Around half the commercially produced oxygen is consumed by the steel industry. The rest is used for manufacturing products such as nitric acid, sulphuric acid, pharmaceuticals, other chemicals, glass, and ceramics, and also for petroleum processing, metal refining and fabrication processes, cutting and welding of metals, effluent treatment, pulp and paper bleaching, combustion of fuels in automobiles, and the burning of fuel in spacecrafts.

Priestley’s prediction coming true?

Referring to his experience of taking large whiffs of the oxygen he had isolated, Priestley had said, “I fancied that my breast felt peculiarly light and easy for some time afterwards. Who can tell but that, in time, this pure air may become a fashionable article in luxury?”

It looks like he has been proved right today. In present times, athletes are known to breathe in oxygen for a while to restore their energy levels. What’s more, oxygen bars have been opened in Japan, the US, South America, and other places, where people pay for breathing pure oxygen to reduce stress and feel refreshed and energised. And with an increasing number of such bars popping up across the world nowadays, one wonders if this is just a fad or a serious cause for worry.

References

  1. Mark H. Thiemens: Oxygen Origins – Nature Chemistry, 4, 66 (2012)
  2. John E. Heffner: The Story of Oxygen – Respiratory Care, January 2013, 58 (1) 18-31
  3. American Chemical Society International Historic Chemical Landmarks: Joseph Priestley and the Discovery of Oxygen. http://www.acs.org/content/acs/en/education/whatischemistry/landmarks/josephpriestleyoxygen.html
  4. Dr. Doug Steward: Oxygen Element Facts – https://www.chemicool.com/elements/oxygen.html
  5. Dr. Doug Steward: Composition of Air – How Air’s Composition was Discovered https://www.chemicool.com/elements/composition-of-air.html
  6. American Museum of Natural History: An Ode to O – https://www.amnh.org/explore/science-bulletins/earth/documentaries/the-rise-of-oxygen/article-an-ode-to-o
  7. Royal Society of Chemistry: Oxygen – Uses and Properties – http://www.rsc.org/periodic-table/element/8/oxygen
  8. WebElements: Oxygen: The Essentials – https://www.webelements.com/oxygen/

Considerations for Extraction, Stabilization and Quantification by PCR for Sensitive Sample such as RNA

 

Author: Andrew J. Birnie, Ph.D.,

is the global life sciences product manager for Cole-Parmer. He gained a Ph.D. in Veterinary Parasitology in 2008 from the University of Glasgow and following some time in research moved to a commercial role within the molecular biology sector.

 

Introduction

The accessibility of PCR and qPCR systems has increased to where they are almost considered a commodity product today. This is certainly the case for end-point PCR systems and some qPCR units also allowing researchers to carry out gene expression analysis more conveniently and quickly. This accessibility has been an innovative development in the community and will continue to move research forward for years to come.

There have been concerns with regards to reverse transcriptase (RT-PCR) and real-time RT-PCR analysis of sensitive sample types such as RNA due to the stability of the sample during process and storage. Just how much impact this has had upon the results may go unknown. Recent advances into techniques such as digital PCR and new advances in extraction stabilization systems have sought to address some of these concerns.

Extraction

In theory, the extraction process is a relatively trivial matter: disrupt the sample’s cellular integrity and collect the released nucleic acids. However, it is never that simple. Multiple factors must be addressed.

When performing any nucleic acid extraction (especially RNA), stability and integrity of that extract must be considered. Samples being extracted in remote field studies must also take into consideration logistical concerns such as power supply, temperature control, availability to equipment, and shipping if samples are not to be tested onsite immediately.

Another concern with general tissue extracts is the heterogeneous mixture of cell states and types being sampled or extracted from. The result of performing an extraction from a mixed population of cell is apparent and will result in a gene expression profile which represents, at best, an average for that cell population. When considering tissue extracts in diseased or infected sample against wild-type expression, care must be taken to limit the number of wild-type cells in the diseased sample as these may affect the expression profile, or the wild-type cells themselves may have an altered gene expression due to proximity to a diseased or infected cell. This has previously been documented when bulk extracts are compared with laser micro-dissected cells. Due to the above, an ability to extract smaller volumes reliably and minimize loss of target material, or in some instances perform expression profiles on one specific cell, has driven the development of single-cell gene expression analysis kits.

The single-cell extraction and gene expression kits typically have few steps and contain reagents for the sample extraction, reverse transcription, a means to inhibit cell-sourced RNase and the qPCR components, making it a rapid system. Due to the small number of targets, the extraction process can have an impact upon the results of the real-time RT-PCR which must be performed quickly. Contaminating DNA can be removed with the inclusion of a DNase treatment step, typical of most RNA extraction systems. The advantages of such kits are apparent as there are limited chances to lose sample, and the target can be the exact cell type that should be profiled. A limitation of such kits could be their apparent high cost per extraction, but the possible advantages of gene profiling experiments from one cell cannot be overlooked.

Other more standard kits, such as silica column-based extraction systems that typically need more starting material than single-cell kits, require multiple liquid handling steps and washes, and require additional heating equipment and centrifugation. These type of extraction systems often require a specific kit for a sample type or to extract either DNA or RNA. Samples once extracted may be subject to degradation unless stored and treated correctly, especially RNA extractions. These kits are more commonly adopted, perhaps in part to the familiarity of the protocols, performance and the cost per extraction can be less than some other approaches.

Development of new extraction systems has continued and recently a novel extraction system has been introduced to the market requiring only two steps, limiting the manual pipetting error which can occur when multiple pipetting steps are required, and can be completed in three minutes at room temperature. The Arcis Sample Prep Kit provides high-quality, PCR-ready templates without the need for additional laboratory equipment such as centrifuges or hot blocks that are required with other approaches. The simplified workflow has maintained high yields and the Arcis Sample Prep Kit is compatible with common applications such as PCR (end-point, RT-qPCR), real-time PCR, isothermal amplification (LAMP), sequencing (Sanger, Pyro and Next Generation) and genetic profiling (electrophoresis).

This novel Arcis Sample Prep Kit relies upon smaller volumes of starting material than some column-based systems and, unlike other products, can extract both DNA and RNA at the same time removing the need and cost associated with having separate DNA and RNA extraction kits. The system is not enzymatic and has an added benefit of stabilizing samples at ambient temperatures, both DNA and RNA, for extended periods of time with minimal impact on Cqs or sample integrity. Stability data currently shows 100+ days for DNA and 6 days for RNA when stored in the Arcis Sample Prep Kit at ambient temperatures. Developments such as the Arcis Sample Prep Kit could enable more robust analysis of transcript levels, especially for those assays which are targeting low target expression, by limiting the degradation common in extracted RNA targets as well as simplify the process of transporting temperature-sensitive nucleic acids between sites as no cold chain logistics would be required in most cases.

Techniques:

qPCR

Controls are key in any scientific approach and developments in the PCR/qPCR field have attempted to limit spurious amplicon production which negatively impacts upon the target experiment’s efficiencies. Polymerases have become better immobilized prior to PCR and primer and probe developments have also helped reduce inappropriate binding and amplification. Buffer formulation for polymerases has also enhanced the performance of polymerases and made them more specific, sensitive and tolerant to difficult templates.

The results of poorly controlled qPCR have been well documented and can have significant impacts on the community and beyond. A well-documented issue which arose from publications in 1998 and 2002 in which an apparent association of the MMR vaccine and bowel inflammation with developmental disorders in children caused a number of incidences where children were not immunized. A number of court cases soon followed.

In these two papers, it was shown that the qPCR data was not correctly controlled and standard operating procedures were not followed, data analysis was incorrect and there were issues associated with the RT steps before the qPCR. The combined effect caused incorrect conclusions.

This and other cases resulted in scientists in the community generating the MIQE (Minimum Information for Publication of Quantitative Real-Time PCR Experiments) guidelines. The goal was to develop guidelines to promote laboratory consistency, help ensure the integrity of scientific literature, and increase transparency of experiments. These guidelines also provide information necessary for providing the minimum information for evaluating and reporting qPCR experiments.

System (PCR hardware) effects must also not be overlooked when carrying out sensitive assays. In general terms, variability across a PCR/qPCR systems thermal block is best limited to as little as possible as variability in temperature control may impact the result. Ideally systems with high uniformity should be used to limit data variability. Systems such as the Eco/Prime Pro from Cole-Parmer which utilise a liquid filled block to deliver best in class uniformity would be examples of such systems.

Digital PCR

Digital PCR (dPCR) was first developed in the mid-90s and recently has grown in popularity due to investment from some of the larger manufacturers. The technique was developed to quantify DNA or RNA transcript copy number as accurately as possible.

dPCR reaction components will be similar to qPCR and often use hydrolysis probes like qPCR. A differentiator from qPCR is that dPCR does not reference an internal control or standard curve instead counting the exact transcript number in the assay. This can increase the accuracy of the measurement when compared to qPCR. dPCR setup differs from qPCR in that after the similar reaction components are assembled, one large reaction mixture will then be partitioned into approximately 20,000 smaller reaction vessels by creating oil droplets within the reaction well. Each oil droplet has within it the required components for PCR to occur, and after amplification each droplet is then scored for presence or absence of the specific target being investigated and a profile for that target generated.

dPCR could still suffer from the issues previously discussed with regards to extraction but will have the advantage of scoring exact transcript number rather than determining this by plotting unknowns against a standard curve. dPCR has also been shown to have advantages in multiplex environments or when high sensitivity is required compared to other techniques.

Conclusion

There are several issues to be addressed when attempting to accurately define the transcript level of a specific target, not all of which have been covered here. Careful selection of an extraction system that helps stabilize and protect targets, especially RNA, or which allows for immediate analysis must be considered. The systems used after extraction must also be considered and careful selection regarding system accuracy may also factor into the decision.

Chemingineering | Unchaining the Blocks

Our columnist Sahasranaman discusses yet another disruptive technology, Blockchain, that has gained wider awareness in recent times, interestingly, due to the famous or infamous ‘meteoric’ rise of the Bitcoin, a cryptocurrency. Blockchain provided the backbone, so to say, for the rocketing of bitcoin.

It may sound simplistic that Blockchain is just a digital platform to enable transactions, but with many unique features built-in, it gives this technology the potential to provide a quantum leap to many industries in a range of functional areas. It provides the security and confidentiality to transactions. It is versatile, providing three models – public, private and hybrid. It is decentralised and without a regulator. And the transaction costs are incredibly lower. Its applications in industries, according to the columnist, are only limited by our imagination. Read the possibilites and potential of this new technology platform.

This column has often focused on topical subjects, and so the final piece of this year cannot but be on Blockchain, the disruptive technology behind Bitcoin, the phenomenon of 2017. The value of Bitcoin after crossing the $1000 threshold on 1st January, leapfrogged to $19000 in mid-December. This spectacular, probably speculative, rise lends a certain notoriety, not just to Bitcoin but Blockchain itself. Bitcoin is just one of the many cryptocurrencies that Blockchain has spawned. As of last month, there were more than 1300 cryptocurrencies, with a market capitalisation in excess of $600 billion. This discourse is about Blockchain, the backbone on which cryptocurrencies, especially Bitcoin, stands tall. But for Bitcoin’s meteoric dazzle, Blockchain would have remained obscured in the shadows.

Blockchain Technology

Blockchain technology is not easy to comprehend, let alone describe in 1000 odd words. What is germane however are its principles that hold out the promise to its adoption in various commercial and industrial applications. It is easy to visualise Blockchain as a distributed digital platform to carry out transactions. Such transactions could be financial, say between two or more banks, or between buyers and sellers. Or they could be an exchange of confidential information like data and knowledge between two or more parties.The salient feature of the Blockchain platform is that it is distributed and decentralised. The transactions occur peer to peer (P2P) without being overseen by a central regulator. The cost of transactions is reduced substantially and this is perhaps the biggest benefit of Blockchain technology. Investment banks estimate that their infrastructure costs would be slashed by an average of 30%.

Types of Blockchain

The information that is exchanged over Blockchain is secure and transparent. They are safe from deletion, revision, and manipulation, leaving behind a trail that can be verified, validated and audited. These are valuable attributes for a business transaction, especially when it comes at a low cost. There are three kinds of Blockchain – public, private and hybrid. Bitcoin, or any other cryptocurrency, is the best example of a public Blockchain, a network that is completely open to everyone to join and participate. A private Blockchain, on the other hand, needs an invitation or permission to join. While individuals within a single business entity are invited to participate in a private Blockchain, a hybrid or consortium Blockchain extends this to several entities in a business cluster. It is the private and hybrid Blockchains that are of great interest to the business enterprise.

Smart Contract

A major application of Blockchain across industries comes in the form of Smart Contract. Smart Contracts are self-executing contracts with the terms of an agreement between two or more parties written into a computer program, that resides on a decentralised Blockchain network. This allows transactions to be carried out without the intervention of an external enforcement mechanism. The transactions are speedy, transparent and auditable. Smart Contracts need not be limited to the financial transactions involved in buying and selling of goods; it can be extended to virtually any process that consists of a sequence of events with the outcome of one event defined as the enabling conditions to start the subsequent event. Such a Smart Contract enabled workflow based on “if-then” principle can be used in an engineering design office to smoothen and speed up the work. It can be used to streamline batch processes. The application of Smart Contract principle in the manufacturing industry is limited only by our imagination.

Supply Chain Management

Blockchain technology has the potential to disrupt many industries; manufacturing is only one among them. The applications of Blockchain in the chemical industry are no different from rest of the manufacturing sector. One of the obvious benefits would be in supply chain management. The chemical industry has a long and complex supply chain and by getting all the parties together on a hybrid Blockchain platform, inventory can be managed transparently. Inventory carrying costs can be brought down significantly. Further, Smart Contracts can be used to reduce the cost and time of transactions.

Internet of Things

The chemical industry has been wary of adopting Internet of Things (IoT), widely touted as the harbinger of a new revolution in manufacturing, due to concerns of security. The industry is rightly worried about the vulnerability of the networks on which the machines communicate with each other. The consequences of a cyber attack on IoT networks can be catastrophic in the chemical industry. Blockchain promises to bring the same level of security to IoT networks as in cryptocurrencies. A lot of research is currently underway on Blockchain-based IoT security. This has the promise to build a robust IoT network that can be trusted by the chemical industry, eventually paving the way for its widespread adoption.

Compliance and Sharing

The integrity and trustworthiness of data on a Blockchain network is useful for those sectors of the chemical industry, pharma and food processing for example, that are governed by external regulators. Instead of managing cumbersome paperwork that fosters mistrust, all concerned parties can be brought on a common platform of trust powered by Blockchain. The regulator’s task of monitoring compliance becomes a cakewalk. The same principle can be used by a cluster of industries to share a common infrastructure, say utilities or CETP. By coming together on a hybrid Blockchain platform, the users can provide real-time data to the utility provider for planning and optimising operations. This argument can be further extended to share best practices by multiple locations of a common business entity. Instead of the conventional practice of reports and annual meetings, where such lessons get distorted and manipulated due to human bias, multiple sites can be linked together on a private Blockchain platform of trust and transparency.

Critics

It must be mentioned here that the applications mentioned above are possible even in a non-Blockchain environment. But Blockchain brings certain unique properties that bear repetition – trust, transparency, integrity and low cost. Blockchain technology is not without its fair share of critics and sceptics. Most of the scepticism flows from viewing the technology through the lens of Bitcoin. Bitcoin is a powerful demonstration of the power and potential of Blockchain, but it is built on a public platform. The number of transactions is so large that it requires a great deal of effort and energy to validate them. This validation is done by gatekeepers, who are known as miners because they are rewarded by a Bitcoin for their efforts. This validation or “proof of work” to use the jargon, requires the miners to perform energy-intense computational work to decipher a code, that can be then appended to the digital transaction. The energy required for this mining is currently estimated to be consuming 0.13% of global electricity and by 2020 is expected to equal the consumption of Denmark. The enterprise-level applications would, however, be on a private or consortium platform, with far fewer transactions requiring only a minuscule amount of power.

The chemical industry has always been conservative in adopting digital technologies and practices. The industry’s giant BASF revealed mid-year that it is working with a start-up to explore the potential of Blockchain in supply chain management. This could unblock the industry’s mindset soon.

Readers’ responses may be sent to:
k.sahasranaman@gmail.com or
chemindigest@gmail.com

Chemingineering | Methanol Economy

A high percentage of fuels produced are used for transportation and most of these like petrol and diesel are from oil & gas. Since long, particularly after sudden oil price hikes, the world has been searching for suitable alternatives. Since 1990s, methanol has been advocated as a viable alternative as it is a good carrier of energy. In this overview, the various developments, the potential and prospects are well presented.

Though India’s methanol economy is yet to take off from the drawing boards, it has begun to make waves in popular media in last few months. Methanol Economy is hardly a new concept, having been advocated as far back as 1990s by the Chemistry Nobel Laureate George Olah. But how we and probably China perceive this new paradigm is different from the way rest of the world does.

Transport Fuel

The attractiveness of methanol as a clean and efficient substitute for petrol is quite well known. Pure methanol has been used as the fuel in the popular Indy Car Races in USA since 1965, primarily from safety considerations. From 1980 to 2005, USA ran a successful methanol campaign, in which tens of thousands of vehicles were converted to operate on M85, consisting of 85% methanol. But in 2005 USA abandoned methanol in favour of crop-based ethanol, in what was clearly a political decision. That leaves China as the biggest user of methanol for transportation. Contributing 55% to the global production, China produces 47 million tonnes of methanol annually. Methanol is blended with petrol in various proportions ranging from 5% to 100%, 15% being the most common. Geely, a Chinese company, has emerged as the world’s leading methanol vehicle manufacturer, with a capacity to produce 200,000 vehicles per annum. China has a current stranglehold on the methanol economy, dominating both production and consumption.

Fuel Cells

But blending with petrol is at best a pitstop on the long and arduous journey of methanol. Many countries, India, France, Britain and Norway among them, have declared their plans to junk internal combustion engine in favour of electric vehicles. India has set an ambitious target of 2030 for going fully electric. How does this stack up with the adoption of methanol economy? The answer is fuel cell.

Electric-powered vehicles have two options to source their power: Battery or Fuel Cell. For long, opinion has been divided equally among experts on which is a better option. But in a survey by KPMG early this year, Fuel Cells found an overwhelming backing from automobile companies, because they don’t need a charging infrastructure. And among Fuel Cells, it is the Direct Methanol Fuel Cell (DMFC) that has the power to propel the methanol economy forward. Invented in 1990s by a host of institutions, including NASA, the DMFC uses an acidic solid polymer, in the form of a membrane, as the electrolyte. Methanol and water react electrochemically to generate power. The DMFC is ideal for transport application compared to the bulky hydrogen based fuel cells because of its high energy density and quick refueling. Daimler Chrysler unveiled the first DMFC powered vehicle in 2000. In 2015, Denmark opened the first methanol refilling station to service DMFC fitted vehicles. However, the efficiency of DMFC is currently poor and improvements are required on the catalysts that make up the electrodes.

Dimethyl Ether

Another potential application of methanol exciting the Indian think tank is using it for production of dimethyl ether (DME). DME has properties that are remarkably similar to LPG. China, the world’s largest producer of DME, used it widely to blend with LPG. But this practice was banned in 2008, following safety concerns. The blended fuel was found to damage the rubber sealants of the LPG cylinders. Despite the ban, the blending of LPG with DME continues to be rampant. DME has also been used as a substitute for diesel with limited success; the issues being poor engine lubrication.

Methanol

At the heart of the Methanol Economy is its production. It is important to remember that methanol is not the source of energy, but only its carrier. Energy derived from other sources, primarily coal, natural gas and biomass, is converted and stored in methanol. The efficiency of this energy conversion process is central to the success of methanol economy. China produces 85% of it methanol from coal and the remaining from natural gas. India also wants to put coal at the centre of its methanol economy. Syngas for methanol synthesis is obtained from natural gas by steam reforming. Coal and biomass have to be gasified first and then cleaned up before syngas can be produced. China has experimented with different types of gasifiers and has a very mature coal gasification technology. India on the other hand has struggled to establish the gasification technology for its high-ash coal. Both coal and natural gas would only be transition fuels before we move on to biomass in order to meet the renewable energy goals of Paris agreement.

Biomethanol

It is the renewable feedstocks that perhaps pose the biggest threat to the methanol economy. The conversion efficiency of biomass to methanol is presently in the range of 50-60%. Biomass gasifiers are available in various designs like fixed bed, fluidised bed, entrained bed etc. These have been successfully demonstrated for locally available biomass. Scale-up, cost reduction and ability to handle diverse feedstocks are key challenges. Another potential threat comes from the still-maturing technology for producing ethanol from cellulosic biomass. Ethanol continues to be lobbied hard in USA. Water consumption is significantly lower for methanol production than ethanol, even after accounting for the methanol’s lower energy density.

Methane Hydrates

No overview of methanol economy can be complete without reference to methane hydrates, deposits of which are believed tobe a larger source of energy than that combined from oil, gas and coal. The current estimate of methane trapped in gas hydrate deposits is in the order of 105 trillion cubic meters, 99% being in ocean sediments. While commercial production of methane from gas hydrates is at least a decade away, a mature Methanol Economy can immensely profit from it. Much research is underway for the biological oxidation of methane to methanol using methanotrophic bacteria.

Holy Grail

The Holy Grail of Methanol Economy would be to capture carbon dioxide from the atmosphere and convert it to methanol. Such a process is indeed feasible and has been patented by George Olah and his team. Hydrogen required to react with carbon dioxide can be generated electrolytically from water using renewable solar energy, for example. This will make Methanol Economy carbon-neutral and truly circular.

Post Script – This column is dedicated to the memory of George Olah, the champion of Methanol Economy, who passed away in March this year.

Readers’ responses may be sent

to k.sahasranaman@gmail.com or

chemindigest@gmail.com

Chemical Industry Digest- November 2017

Articles Covered in this Issue:

1. Introduction to IIoT and its applications in the chemical industry
Rohit Pimpley, Forbes Marshall Ltd
Defines and explains IIoT and outlines some of the key applications in the chemical industry.

2. Digital transformation of the chemical industry
G Ganapathiraman, ARC Advisory Group, India
Digitisation is transforming the chemical industry and IIoT is one great development of this that is expected to bring about enormous change by significantly reducing the complexity of working. In what all ways IIoT impacts and enables the chemical industry are described.

3. A Real-world approach to the IIoT for process reliability
Bart Winters, Francois Leclerc, Honeywell Process Solutions
Operating at optimal efficiency is important for process plants. IIoT enables plant operators to improve process reliability through analysis of captured data. This article describes how IIoT can support continuous improvement and address previously unsolved problems to improve plant availability, safety, and reliability.

4. Piping stress analysis primer
S. Raghava Chari – Consultant
A comprehensive dossier on piping stress from the sources of such stresses to its management and on preventing failures. Detailed very well through case studies and useful do’s and don’ts.

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